McGeer and Associates Laboratory
Kinsmen Laboratory of Neurological Research, University of British Columbia, Vancouver Canada

Patrick L McGeer, MD,PhD, FRCP(C), FRSC, is a professor emeritus, Faculty of Medicine, UBC. He graduated with first class honors in chemistry from UBC in 1948 and received his PhD in chemistry from Princeton University in 1951. He worked for the DuPont Company in Wilmington, Delaware from 1951 to 1954, where he met his wife, Dr. Edith McGeer.  He then entered medical school receiving his MD from UBC in 1958.  He is a fellow of the American Association for the Advancement of Science, the Royal College of Physicians of Canada and the Royal Society of Canada.  He is an Officer of the Order of Canada and a member of the Order of British Columbia . For many years, he combined his scientific career with politics, serving as an opposition member in the British Columbia Legislature from 1962 to 1975, and as a Minister of the Crown in the British Columbia Cabinet from 1975 to 1986.  In Government, he held various portfolios including Education, Universities, Science, Communications and International Trade. While serving in the B.C. Cabinet, he was officially on leave of absence from UBC but continued to work evenings and weekends in the laboratory.  During that period he produced some 150 scientific papers and the first edition of the Molecular Biology of the Mammalian Brain with Sir John Eccles and Edith McGeer.

Dr. McGeer has always been interested in sports He was a conference scoring champion and all star basketball player at UBC and his team defeated the Harlem Globe Trotters. He played basketball for Canada ’s Olympic team in 1948.  He is a member of the UBC Sports Halls of Fame and a team member of the British Columbia Sports Hall of Fame.  With his wife he is the author of over 760 scientific publications. They now direct the Kinsmen Laboratory research program to eliminate dementia sponsored by the Pacific Alzheimer Research Foundation program.

Contact Dr. P.L. McGeer here.


Edith G. McGeer, PhD, FRSC is a professor emerita in the Faculty of Medicine at UBC. She was born in New York City in 1923. She received her BA from Swarthmore College and her PhD from the University of Virginia at the age of 22.  She worked for the DuPont Company in Wilmington Delaware, winning three patents and a citation from the Delaware section of the American Chemical Society before moving with her husband to Vancouver when he entered UBC’s medical school.  She has served on the editorial boards of 15 international journals in the neuroscience field, and on numerous scientific review boards, particularly for the National Institutes of Health in the United States.  She was one of the initial members of the Executive Committee of the World Federation of Neurology Group on the Dementias. She is a Fellow of the Royal Society of Canada, an Officer of the Order of Canada and a member of the Order of British Columbia. With her husband she has more than 700 scientific publications and is co-director of the Kinsmen Laboratory program to eliminate dementia. 

 


Dr. Jian Ping (Jimmy) Guo received his MD in China from the Hunan Medical University , Changsha, China in 1984. He received his MSc degree in Virology and Immunology from Hunan Medical University in 1987 and his PhD in biochemistry from the Institute of Hepatology , Beijing Medical University in 1993. He then became an Associate Professor at the Institute of Hepatology before immigrating to Canada in 1995 as a post doctoral fellow in the Department of Ophthalmology at the University of British Columbia . In 1997 he became Director of the Research Laboratory of International Newtech Development Inc. of Delta, BC, Canada and in 2001 Director of R&D at Clinotech Diagnostics and Pharmaceuticals Inc. of Richmond, BC, Canada . In 2002 he joined the Kinsmen Laboratory of Neurological Research as a Research Associate. He has had experience in developing vaccines and antibodies against hepatitis virus B and C, as well as test kits for early diagnosis of stroke and brain injury, and new mammalian cell lines. He is currently studying novel therapeutic approaches for the treatment of AD and other dementias. These are partly based on synthesizing peptide arrays to discover novel amyloid-beta blocking compounds and screening synthetic compounds and natural biological products for their ability to block amyloid-beta aggregation. While in China he received a highly prestigious “Excellent Young Scientist” award from the Chinese Medical Sciences Association. 

Contact Dr. JP Guo here.



Dr. Hong Qing received his Ph.D. in Neurobiology at the Sun Yat-sen University of Medical Sciences in Guangzhou, China in 1996. He did post doctoral studies in the Department of Oncology at Emory University from 1997-2000 and in the Neuropsychiatric Research Unit at the University of Saskatchewan from 2000-2001. He then joined the Laboratory of Dr Weihong Song at the University of British Columbia. He is currently a Research Associate in the Department of Psychiatry at UBC. His research interested in the biochemistry and molecular cell biology of neuronal degeneration during aging of the mammalian brain, particularly in Alzheimer's (AD) and Parkinson's (PD) diseases. The major project focuses on elucidation of the pathogenic mechanisms of Alzheimer's and Parkinson's diseases.
Dr. Qing is also an adjunct professor in the Department of Biotechnology, School of Life Science and Technology, Beijing Institute of Technology, China. His study examines Dracaena cochinchinensis, which is a Mega-projects of Science Research of the Ministry of Science and Technology of the People's Republic of China.


Contact Dr. H. Qing here.



Dr. Claudia Schwab completed her M.S. in 1986 and her Ph.D. in 1990 at the University of Leipzig, Germany, studying mouse models of Alzheimer’s disease. As a postdoctoral fellow she studied cytoskeletal degeneration with Dr. J.W. Geddes at the University of Kentucky in Lexington, KY. In 1993 she joined the McGeer Lab at UBC. She is currently a Research Associate in the Department of Psychiatry at UBC. Her research interests lie in the pathogenesis of neurodegenerative disorders, including Alzheimer disease, Parkinson disease, and Dementia with Lewy Bodies, especially in those aspects involving inflammatory processes and protein aggregation. She mainly employs immunohistochemistry, with the aim of correlating brain pathology in human brain specimens with animal and cell culture models. She has published over 60 peer reviewed publications, plus several book chapters and non-reviewed papers. She also teaches in the UBC Departments of Medicine and Pharmacology & Therapeutics.

Contact Dr. C. Schwab here.



Dr. Sadayuki Hashioka graduated from the Faculty of Medicine, University of Miyazaki ( Miyazaki, Japan ) in 1998. From 1998 to 2002, he worked as a psychiatrist mainly at Kyushu University Hospital in Fukuoka, Japan . He then entered the Graduate School of Medical Sciences at Kyushu University receiving his PhD in 2006. His studies were on the relationship between the aggregation state of beta amyloid protein and microglial activation. Since 2006 he has been a postdoctoral fellow in the Kinsmen Laboratory of Neurological Research, Department of Psychiatry, University of British Columbia . His main research theme is neuroinflammation and associated microglial and astrocytic toxicity in neurodegenerative diseases.

Contact Dr. S. Hashioka here.



Dr. Moonhee Lee received his BSc. (Hon) in 1992 and his MSc. in1994 in the department of Genetic Engineering, Kyungpook National University (KNU), Korea . He then entered the Department of Biomedical Science, University of Sheffield, UK finishing his PhD in November 2006. He returned to KNU for postdoctoral work until May 2008 when he took up a postdoctoral position in the Kinsmen Laboratory of Neurological Research. He has research experience a wide range of areas including oxidative stress, antioxidant defense, protein aggregates, nitric oxide in neurodegenerative diseases, ion channels, P2X receptors, voltage-gated calcium channels, synaptic plasticity and aquaporins and edema, phosphatidylserine and its specific binding proteins, and phagocytosis. His current research projects are the effects on hydrogen sulfide on microglial activation and neurodegenerative diseases. 

Contact Dr. M. Lee here.



Dr. Tetsuaki Arai graduated in 1990 from the University of Tsukuba in Japan. He then worked for the following 6.5 years as a psychiatrist in the Department of Psychiatry, Institute of Clinical Medicine, University of Tsukuba and in the Tokyo Metropolitan Matsuzawa Hospital. Subsequently, he became a researcher in Department of Neuropathology, Tokyo Institute of Psychiatry, studying the neuropathology of Alzheimer's disease and other dementias. He obtained his PhD in 2001 with a focus on the neuropathology and biochemistry of tauopathies, including progressive supranuclear palsy, corticobasal degeneration and Pick's disease. Then, he worked from 2003-2005 as a postdoctoral research fellow with the McGeer team in Kinsmen Laboratory of Neurological Research, University of British Columbia. Afterwards, he came back to Tokyo Institute of Psychiatry continuing as a researcher there. Currently, his research is focused on the neuropathology and biochemistry of neurodegenerative disorders. He is particularly interested in intracellular abnormal protein aggregation, including tauopathies and TDP-43 proteinopathies.



Originally from Latvia, Dr. Andis Klegeris graduated with a M.Sc. in Biophysics from Moscow State Medical University . He then entered Oxford University, UK  where he received his D Phil   in Pharmacology in 1995.Towards the end of his studies at Oxford he became interested in inflammatory responses of the central nervous system particularly involving microglial cells. This led him to the University of British Columbia for post-doctoral studies in the Kinsmen Laboratory of Neurological Research.  He was promoted to Research Associate in the Department of Psychiatry in 1999 and, in 2007 became an Assistant Professor of Pharmacology in the Department of Biology, UBC Okanagan in Kelowna , B.C.  Identification of novel treatment options for neurodegenerative disease is the main research focus of the Laboratory of Cellular and Molecular Pharmacology which is currently under development. He teaches undergraduate courses in pharmacology and biochemistry.  

Contact Dr. A. Klegeris here.



Dr. Judy Miklossy received her MD, PhD degrees and certificates of specialization in neurology, psychiatry and psychotherapy (EU and AELE conform) at the Faculty of Medicine, University of Debrecen, Hungary. She received the titles of Privatdozent and Master of Education and Research (MER) equivalent of DSc and assistant Professor and the certificate of specialization in neuropathology at the University of Lausanne and the Swiss Medical Federation (FMH). She was head of the Neurodegeneration research group at the University Institute of Pathology, CHUV, Lausanne, Switzerland. She participated in molecular biology research at Temple University, Philadelphia, USA, and helped to introduce Alzheimer's disease research. She was head of the neuropathology lab of the Kinsmen Laboratory of Neurological Research, University of British Columbia, Vancouver, Canada between 2004 and 2007. She is founder and presently director of the Prevention Alzheimer International Foundation and International Alzheimer Research Center in Switzerland. She has a clinical practice in Neurology, Vigimed Medical Center, Martigny, Switzerland which specializes in memory consultation and Lyme disease. She has been actively involved in research on Alzheimer's disease, other neurodegenerative diseases and Lyme disease for over 25 years. She is a member of the Scientific Advisory Board of the Canadian Lyme Foundation and the Deutsche Borreliose Gesellschaft. 

Contact Dr. J. Miklossy here.



Dr. John C. Steele is from a Toronto family of physicians and his training in neurology during the 1960s was with Clifford Richardson, Henry Barnett and Jerzy Olszewski, and then at Queen Square with Roger Gilliat and Dennis Williams. In the 1970s he was attracted by the beauty of Pacific islands and harmonious life styles of their people, and for 10 years he worked in Micronesia to improve its health care system. In 1982, he joined the Navy Hospital on Guam as a neurologist and began studies of lytico-bodig, the amyotrophic lateral sclerosis/Parkinsonism-dementia complex (ALS/PDC), a unique disease of this small island with features of progressive nuclear palsy (PSP), Parkinson’s disease, Alzheimer’s disease and cortico-basal degeneration. More information about ALS/PDC on Dr Steele’s website . He and his colleagues discovered PSP which was originally known as the Steele-Richardson-Olszewski syndrome (see reference 7 in his publications). He has unique experience in observing the manifestations of movement disorders and dementing illnesses, not just on Guam, but in locations around the world.

Contact Dr. J.C. Steele here.